RecruitingNCT05943834

Early Detection of Alzheimer's Disease and Affective Disorders by Automated Voice and Speech Analysis (PLATA)

Early Detection of Alzheimer's Disease and Affective Disorders by Automated Voice and Speech Analysis

Sponsor

Centre Hospitalier Universitaire de Nice

Enrollment

100 participants

Start Date

Jul 13, 2023

Study Type

OBSERVATIONAL

Conditions

Neurocognitive Disorders

Summary

PLATA aims to develop an algorithm to identify vocal biomarkers of Alzheimer's dementia. Using data collected as part of routine care, speech patterns will be compared to known biomarkers of Alzheimer's disease, such as amyloid 1-42 and p-Tau in CSF (cerebrospinal fluid). If biomarkers of speech can be identified in Alzheimer's disease, it is possible that patients and research participants will no longer need to undergo need to undergo the intensive and invasive baseline biomarker methods currently used, such as lumbar punctures and PET scans.

Eligibility

Min Age: 50 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This study (called PLATA) is investigating whether automated analysis of a person's voice and speech patterns can detect early signs of Alzheimer's disease or mood disorders such as depression. The goal is to find a simple, non-invasive way to identify cognitive changes earlier than current tests allow. **You may be eligible if...** - You are 50 or older - You have relevant biomarker and neuropsychological test results already available - You have normal cognition or only very mild memory changes (CDR score of 0 or 0.5) - You have sufficient understanding of the study language to complete questionnaires **You may NOT be eligible if...** - You have significant hearing problems - You are under legal guardianship or a protective legal arrangement - You are unable to participate in a clinical study under French public health law Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERSeries of cognitive tasks during a semi-automated call

Tasks: * Verbal learning recall (immediate) or Story Recall task (immediate) * Narrative Storytelling /free speech * Verbal fluency task * Verbal learning recall (delayed) or Story Recall task (delayed)