RecruitingNot ApplicableNCT07526740

Brain Stimulation and Cognitive Training for MCI

Combining Brain Stimulation With Computerized Cognitive Training for MCI

Sponsor

Medical University of South Carolina

Enrollment

50 participants

Start Date

Mar 16, 2026

Study Type

INTERVENTIONAL

Conditions

Mild Neurocognitive Disorder Cognitive Dysfunction Mild Cognitive Impairment (MCI)Neurocognitive Disorders Cognition Disorders

Summary

This is a randomized clinical trial of a treatment that combines non-invasive brain stimulation with computerized cognitive training (CCT) for people with mild cognitive impairment (MCI). The form of brain stimulation used in this study is accelerated intermittent theta burst stimulation (iTBS). All participants receive the same amount of iTBS and are randomly assigned to engage in one of two types of CCT. The goals of the study are to see if this combined treatment is feasible and acceptable to people with MCI and whether combined iTBS and CCT improves memory, thinking skills, mood, and daily function.

Eligibility

Min Age: 60 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called Accelerated iTBS, a medical device called Computerized Cognitive Training, and others for people with cognition disorders, cognitive dysfunction, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 60 Years to 85 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEAccelerated iTBS

A MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System with Brainsight neuronavigation will be used. All participants will receive active treatment: 12 sessions (3 min each) of iTBS on each of 3 treatment days within an 8-day span. A single session = 600 pulses of 50 Hz iTBS triplets delivered every 200ms in 2s trains repeated every 10s (8s inter-train interval) for 190s. Stimulation intensity is 120% resting motor threshold (rMT) delivered at the left dorsolateral prefrontal cortex. Total pulses = 21,600. Inter-session intervals will be approx. 15 min.

DEVICEComputerized Cognitive Training

CCT will be delivered through the online BrainHQ platform. Participants will engage in adaptive visual speed of processing training during the 15-min breaks between iTBS sessions (11 sessions on each treatment day, total CCT time = 495 min).

DEVICESham Computerized Cognitive Training

Sham CCT will be delivered through the online BrainHQ platform. Participants will engage in non-adaptive control games during the 15-min breaks between iTBS sessions (11 sessions on each treatment day, total sham CCT time = 495 min).