Study Comparing Negative Pressure Dressing vs Conventional in Patients With Resected STS After Radiotherapy

This study is comparing two types of wound dressings after surgery for soft tissue sarcoma (a cancer of fat, muscle, or connective tissue) in patients who received radiation before their operation. Researchers want to see if a special vacuum-assisted dressing (negative pressure wound therapy) reduces wound complications better than a standard dressing. **You may be eligible if...** - You are 18 or older - You have a soft tissue sarcoma of the limb or trunk and received radiation before surgery - You are scheduled for surgery 3–8 weeks after completing radiation, with the goal of removing all the cancer - Your wound is expected to be closed directly (primary closure) - You have medical insurance and are willing to attend follow-up visits **You may NOT be eligible if...** - You have a known allergy to silver (used in the dressings) - Your sarcoma is Ewing's sarcoma, chondrosarcoma, osteosarcoma, or desmoid tumor - Your wound cannot be closed and requires skin grafting Talk to your doctor to see if this trial is right for you.