Continuation Of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural Effusion
Continuation Of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural Effusion (COSINE)
Guy's and St Thomas' NHS Foundation Trust
124 participants
Nov 15, 2023
OBSERVATIONAL
Conditions
Summary
The aim of this study is to better understand the relationship between pleural effusions and breathlessness in patients with unilateral pleural effusions and breathlessness who require pleural fluid removal for its management.
Eligibility
Inclusion Criteria5
- Age 18 years or above
- Has a unilateral pleural effusion AND
- require thoracocentesis OR
- chest drain insertion (main study only) OR
- has an IPC in situ (main study only)
Exclusion Criteria5
- Inability to consent
- Any contraindications to the proposed pleural procedure
- Haemodynamic or clinical instability that precludes from the safe completion of required pre-procedural measurements
- Inability to identify surface landmarks for surface EMG electrode placement
- Past medical history of diaphragmatic paralysis (diaphragm sub study only)
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
The surface parasternal EMG of participants will be measured pre, immediately post and at days 1 and 7 following pleural fluid removal
The ipsilateral and contralateral surface diaphragm EMG of participants will be measured pre and immediately post pleural fluid removal
The thickness of the parasternal intercostal muscle of participants will be measured using thoracic ultrasound pre and immediately post pleural fluid removal
The VAS breathlessness score and Dyspnoea-12 questionnaire of participants will be measured pre, immediately post and at days 1 and 7 following pleural fluid removal
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05945043