RecruitingNot ApplicableNCT05945641

Effect of Low-load Resistance Training vs. High-intensity Interval Training on Local Muscle Endurance

The Effect of Low-Load Resistance Training Versus High-intensity/Sprint Interval Training on Local Muscle Endurance, Mitochondrial Content, Mitochondrial Function, and Muscle Capillarization


Sponsor

University of British Columbia

Enrollment

20 participants

Start Date

Sep 27, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Local muscle endurance (LME) is the ability of a muscle(s) to resist fatigue and is needed for daily activities of life such as climbing stairs, lifting/moving objects, and in sport contexts like rock climbing, mixed martial arts, cross-fit, kayaking and canoeing. Therefore, the investigators want learn how to improve LME and understand what in human bodies changes during exercise training to cause these changes. The investigators know that lifting weights improves muscle strength which is believed to improve LME. Specifically lifting less heavy weights (LLRET) for more repetitions leads to greater gains in LME opposed to heavier weights for fewer repetitions. Therefore, lifting less heavy weights likely causes greater changes in our muscles than lifting heavier weights that cause improvements in LME. Aerobic exercise preformed at high intensities in an interval format (HIIT) may also help improve LME by increasing our muscle's ability to produce energy during exercise. Therefore, the investigators want to see which of LLRET or HIIT leads to greater improvements in LME.


Eligibility

Min Age: 19 YearsMax Age: 30 Years

Plain Language Summary

Simplified for easier understanding

This study compares two training methods — low-load resistance exercise training (LLRET, lifting lighter weights for more repetitions) and high-intensity interval training (HIIT, short bursts of intense aerobic exercise) — to see which approach better improves local muscle endurance, or the ability of a muscle to resist fatigue over repeated contractions. Researchers will also look at changes in muscle biology, such as mitochondrial function and muscle capillarization, that may explain differences in performance gains. Healthy, untrained adults aged 19–30 with a BMI between 18 and 30 who have not engaged in more than 2 hours per week of structured exercise over the past year are eligible; people with cardiovascular disease, diabetes, cancer, or certain medications are excluded. Participation involves completing either LLRET or HIIT sessions over the study period, along with muscle assessments before and after training. This summary was prepared as patient-facing educational content using AI assistance.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALLow Load Resistance training

Performing single leg knee extension exercise with using equivalent to \~30%1-RM to failure,

BEHAVIORALSprint/High Intensity Interval Training

Performing repeated submaximal/maximal 30second-60 seconds (1-3 minute rest between) aerobic intervals on a Kicking ergometer (modified bike that allows cycling to be performed with one leg using a kicking motion).


Locations(1)

Univeristy if British Columbia

Vancouver, British Columbia, Canada

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NCT05945641


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