IVIM & OLINK in Sarcoma
Prospective Study of Image and Blood-derived Biomarkers to Predict Metastasis in Soft-tissue Sarcomas
University Health Network, Toronto
145 participants
Mar 5, 2024
INTERVENTIONAL
Conditions
Summary
The hypoxia \> metastasis axis suggests that a DWI-based biomarker of hypoxia incorporating IVIM may be able to predict metastasis in STS patients, ultimately enabling stratification for personalized treatments at the time of diagnostic (MR) imaging, without adding an excessive burden to the patient or clinical workflow (typical DWI/IVIM sequences can be acquired acquired in approximately 5 minutes).
Eligibility
Inclusion Criteria3
- Age ≥ 18 years
- Ability to understand and the willingness to sign a written informed consent document
- Grade 2 or 3 soft tissue sarcoma greater than 5 cm in largest dimension
Exclusion Criteria1
- Contraindication to MRI scan as per current institutional guidelines (for patients requiring MRI)
Interventions
Standard of care pre-operative radiotherapy
Standard of care definitive surgery
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05950594