RecruitingNot ApplicableNCT05950607

Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0

Trial to Reduce Antimicrobial Use In Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0 (TRAIN-AD 2.0)

Sponsor

Hebrew SeniorLife

Enrollment

750 participants

Start Date

Nov 13, 2023

Study Type

INTERVENTIONAL

Conditions

Dementia Infections Alzheimer Disease

Summary

The goal of this pragmatic cluster randomized clinical trial is to compare management of suspected infection in nursing home residents with dementia The main questions it aims to answer whether residents with dementia in nursing homes randomized to use a multicomponent intervention to optimize suspected infection management ( versus usual care) use less antibiotics and fewer burdensome interventions.

Eligibility

Min Age: 60 YearsMax Age: 106 Years

Plain Language Summary

Simplified for easier understanding

This study is testing new strategies to reduce unnecessary antibiotic use in nursing home residents who have Alzheimer's disease or another form of dementia. Overuse of antibiotics in this population is a major health concern and the study aims to find safer, smarter approaches to infection management. **You may be eligible if...** - You are over 60 years old - You have a diagnosis of dementia (any type) - You have been living in the nursing home for more than 90 days - You have at least mild cognitive impairment on a standard scale **You may NOT be eligible if...** - You are under 60 years old - You have been in the nursing home for less than 90 days - You do not have a dementia diagnosis - Your cognitive screening score does not meet the required threshold Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALTRAIN AD 2.0

The study intervention is a multi-component training program targeting direct care providers and healthcare proxies for NH residents with moderate to advanced dementia intended to improve the management of urinary tract infections (UTIs) and lower respiratory tract infections (LRIs). The components include: A. Provider Orientation: At NH start-up and q2 months providers will be offered orientations sessions involving two 15-minute presentations, one focused on the background and rationale for the program and one focused on describing the program components. B. A case-based on-line course, "Infection Management in Moderate to Advanced Dementia," C. Posters and pocket cards for providers displaying algorithms guiding appropriate antimicrobial initiation for suspected UTIs and LRIs that integrate patient preferences, and D. Proxies of ALL residents in the facility will be sent a booklet related to infection management for persons with moderate to advanced dementia. .