RecruitingNot ApplicableNCT05954702

Supercharged TRAM Evaluation in Cervical Esophagogastroplasty After Esophagectomy


Sponsor

Instituto do Cancer do Estado de São Paulo

Enrollment

60 participants

Start Date

Jul 21, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Esophagectomy has high rates of morbidity and mortality, in many cases due to esophagus reconstruction. Anastomotic leakage and fistula are the main esophagectomy complications. Many studies underwent to investigate the cause for anastomotic leakage after esophagectomy, however none of them conclude it is related to surgery or suture technique. However, it seems to be triggered by the ischemia caused after stomach mobilization to esophagus reconstruction, or even tension in the anastomosis. Considering the post esophagectomy with gastroplasty high morbidity and mortality rates, strategies to create a new vascularization source and decrease anastomotic leakage rates is important. In this study researchers will evaluate whether a TRAM flap transfer supercharged is effective on decrease morbidity related to anastomosis ischemia in patients undergoing esophagectomy.


Eligibility

Min Age: 18 Years

Inclusion Criteria2

  • Diagnosis of esophageal malignancy cancer;
  • Ability to understand and collaborate during treatment;

Exclusion Criteria3

  • Previous gastrectomy;
  • Previous abdominal surgery with risk of altering stomach vascularization;
  • Previous head and neck surgery with risk of alteration of cervical vessels.

Interventions

PROCEDURESupercharged TRAM esophagectomy

Esophagectomy, immediately followed by supercharged esophagogastroplasty. Use the transverse rectus abdominis myocutaneous (TRAM) flap transfers to surgically create a new anastomosis in the left gastroepiploic vessels.

PROCEDUREConventional Esophagectomy

Esophagectomy, immediately followed by an esophagus reconstruction trough esophagogastroplasty.


Locations(1)

Instituto do Cancer do Estado de São Paulo (ICESP)

São Paulo, São Paulo, Brazil

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NCT05954702


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