Esophagus Cancer Clinical Trials

22 recruiting

Esophagus Cancer Trials at a Glance

25 actively recruiting trials for esophagus cancer are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 7 trials, with the heaviest enrollment activity in Beijing, Anyang, and Nanjing. Lead sponsors running esophagus cancer studies include Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Chongqing Precision Biotech Co., Ltd, and Cedars-Sinai Medical Center.

Browse esophagus cancer trials by phase

Treatments under study

About Esophagus Cancer Clinical Trials

Looking for clinical trials for Esophagus Cancer? There are currently 22 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Esophagus Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Esophagus Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 25 trials

Recruiting
Phase 1

CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer

Esophageal CancerGastric CancerEsophagus Cancer+1 more
Washington University School of Medicine42 enrolled1 locationNCT05187182
Recruiting

Mayo Clinic Upper Digestive Disease Survey

Esophageal CancerEsophagus CancerEsophageal Neoplasms+6 more
Mayo Clinic1,000 enrolled1 locationNCT02530983
Recruiting

Multimodal Deep Learning for Predicting Treatment Response to Neoadjuvant Chemoimmunotherapy in Esophageal Cancer

Esophagus Cancer
Central South University200 enrolled1 locationNCT07063901
Recruiting

Retrospective Review of Esophageal Cancer at MSKCC

Esophageal CancerEsophagus Cancer
Memorial Sloan Kettering Cancer Center4,000 enrolled1 locationNCT05706558
Recruiting
Phase 2

Predicting Esophageal Cancer Borders Using PET-Imaging

Esophagus Cancer, Stage IEsophagus Cancer, Stage II
University Hospital Heidelberg30 enrolled1 locationNCT06408116
Recruiting
Phase 2

Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEA

Esophagus CancerStomach CancerStomach Cancer Stage IV
Massachusetts General Hospital40 enrolled2 locationsNCT07070466
Recruiting

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

Breast CancerLiver CancerEsophageal Cancer+35 more
UMC Utrecht8,000 enrolled18 locationsNCT04075305
Recruiting
Not Applicable

Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

Liver CancerBiliary Tract CancerColon Cancer+76 more
Cedars-Sinai Medical Center360 enrolled1 locationNCT04907643
Recruiting
Phase 3

Chemoradiotherapy in Esophageal or Esophagogastric Junction Cancer

Esophagus CancerChemotherapy EffectTargeted Therapy+3 more
Cancer Institute and Hospital, Chinese Academy of Medical Sciences2,000 enrolled5 locationsNCT04821778
Recruiting
Not Applicable

Target-specific immunoPET Imaging of Digestive System Carcinoma

MalignancyLiver CancerPancreatic Cancer+12 more
RenJi Hospital400 enrolled1 locationNCT06715839
Recruiting
Phase 1Phase 2

A Trial of the Combination of Afatinib and Palbociclib in Previously Treated Advanced Esophageal Squamous Cell Carcinoma

Esophagus Cancer
West China Hospital45 enrolled1 locationNCT06753747
Recruiting

Endoluminal Vacuum Therapy to Prevent Anastomotic Leakage After Esophagectomy Due to Esophageal Cancer

Esophageal CancerEsophagus CancerAnastomotic Leak
Aesculap AG44 enrolled1 locationNCT06097078
Recruiting
Not Applicable

Proton Therapy for Esophageal Cancer

Esophagus Cancer
Loma Linda University38 enrolled1 locationNCT01684904
Recruiting
Not Applicable

Chemoradiation Versus Esophagectomy for Locally Advanced Esophageal Cancer

Esophagus Cancer
The First Affiliated Hospital of Henan University of Science and Technology196 enrolled2 locationsNCT02972372
Recruiting
Phase 2

Neoadjuvant Comprehensive Treatment for Unresectable Esophageal Cancer

Esophagus Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences90 enrolled1 locationNCT06430658
Recruiting

HER2 Status in Esophagogastric Adenocarcinoma and Its Associations With Patient's Clinicopathological Outcomes

Gastric CancerEsophagus CancerHER2-positive Cancer+1 more
St. James's Hospital, Ireland2,188 enrolled1 locationNCT06550063
Recruiting
Not Applicable

Goal-directed Enteral Nutritional Perioperative Management

Esophagus Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences400 enrolled17 locationsNCT06510543
Recruiting

Multicenter Cohort Study of ESD and Chemo-radiotherapy for High-risk Early-stage Esophageal Cancer

Esophagus Cancer
Second Affiliated Hospital, School of Medicine, Zhejiang University120 enrolled2 locationsNCT06385717
Recruiting
Phase 2

Induction Tislelizumab Combined With Chemotherapy Followed by Definitive Chemoradiotherapy in the Treatment of Locally Unresectable Esophageal Squamous Cell Carcinoma

Immunotherapy Esophagus Cancer
Fuzhou General Hospital93 enrolled1 locationNCT05515315
Recruiting
Phase 1Phase 2

Chemoradiotherapy in Elderly Patients With Oesophagus Cancer

Elderly PatientsOesophagus Cancer
Centre Hospitalier Universitaire de Besancon54 enrolled1 locationNCT02735057