RecruitingNCT05706558
Retrospective Review of Esophageal Cancer at MSKCC
Sponsor
Memorial Sloan Kettering Cancer Center
Enrollment
4,000 participants
Start Date
Dec 13, 2016
Study Type
OBSERVATIONAL
Conditions
Summary
Residual tumor at the proximal or distal margin after esophagectomy is a known prognostic factor for poor survival outcomes in patients with esophageal cancer; however, the significance of the circumferential resection margin (CRM) remains controversial. In this study, the investigators sought to evaluate the prognostic significance of the CRM in patients with esophageal cancer undergoing resection.
Eligibility
Min Age: 18 Years
Inclusion Criteria2
- Histologically confirmed esophageal adenocarcinoma (EAC) or esophageal squamous cell carcinoma (ESCC) undergoing esophagectomy
- Pathologic staged T3 tumors (pT3)
Exclusion Criteria5
- Pathologic staged T0-2 (pT0-2) or T4 tumors (pT4)
- Patients with histologic types other than EAC or ESCC, dysplasia or carcinoma in situ without tumor invasion,
- Patients undergoing salvage esophagectomy
- Evidence of distant metastatic disease
- Patients with a positive proximal or distal margin
Interventions
PROCEDUREEsophagectomy
Esophagectomy
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05706558
Related Trials
CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer
NCT051871821 location
Resilience and Equity in Aging, Cancer, and Health (REACH)
NCT046742671 location
Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)
NCT0646994443 locations
Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.
NCT0721770410 locations
Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)
NCT0644597243 locations