A Study of SI-B003 and BL-B01D1+SI-B003 in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer, Nasopharyngeal Carcinoma and Other Solid Tumors

This study is testing two experimental drugs — SI-B003 alone and SI-B003 combined with BL-B01D1 — in patients with advanced solid tumors including non-small cell lung cancer and nasopharyngeal carcinoma (a type of head and neck cancer). The goal is to assess how safe these treatments are and how well they work. **You may be eligible if...** - You are 18 to 75 years old with a confirmed advanced or metastatic solid tumor - Your cancer has measurable disease and your general health is good (ECOG 0 or 1) - Your major organs (heart, liver, kidneys) are functioning adequately - You have recovered from side effects of prior treatments **You may NOT be eligible if...** - You received chemotherapy or immunotherapy within 4 weeks of starting - You previously had severe immune-related side effects (grade 3 or higher) from immunotherapy - You have an active autoimmune disease, HIV, active hepatitis B or C - You have active brain metastases, a history of organ transplant, or severe heart disease - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.