Short-term Fat Overfeeding on the Effects of Liver Metabolism
The Effect of Short-term Overconsumption of Specific Dietary Nutrients on Liver and Adipose Tissue Metabolism.
University of Oxford
26 participants
Feb 15, 2023
INTERVENTIONAL
Conditions
Summary
Despite work showing the overconsumption of saturated fatty acids (SFA) to be metabolically deleterious, debate continues about whether there is a link between SFA and cardiovascular disease risk. To explore this, we are undertaking a human in vivo parallel-design study, comparing two isocaloric high-fat diets; one enriched with SFA and the other enriched with unsaturated fatty acids (UFAs), to determine the impact of dietary fat composition on postprandial metabolism, liver fat, cardiac fat and cardiac function.
Eligibility
Plain Language Summary
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Interventions
High fat (\~60% of total energy intake) diet enriched with either SFA or UFA
Locations(1)
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NCT05962190