RecruitingNot ApplicableNCT05968859

A Study of Pulmonary Hypertension Peripheral Limitations

Peripheral Limitations in Pulmonary Hypertension and Effects of Muscle Training - The PH Training Trial

Sponsor

Mayo Clinic

Enrollment

45 participants

Start Date

Jan 2, 2024

Study Type

INTERVENTIONAL

Conditions

Healthy Pulmonary Arterial Hypertension

Summary

The investigators are doing this research study to compare whole body aerobic training with isolated leg training (with weights) and its impact on effectiveness in symptoms and quality of life in patients with Pulmonary Arterial Hypertension (PAH).

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is examining why people with pulmonary arterial hypertension (PAH) — a condition where blood pressure in the lung arteries becomes dangerously high — feel short of breath even when their heart and lungs may look relatively normal. Researchers believe there may be limitations in the muscles and blood flow outside of the heart and lungs. Participants undergo exercise testing while heart pressures are measured directly (right heart catheterization) to understand what is happening during physical activity. **You may be eligible if...** - You have a confirmed diagnosis of pulmonary arterial hypertension verified by a catheter-based heart test - You have symptoms (NYHA Class II–IV) and are scheduled for an exercise heart catheterization test - Your heart pumping function is at least 40% - You have not been hospitalized for heart failure in the past 30 days - Healthy volunteers without heart failure are also eligible as a comparison group **You may NOT be eligible if...** - You had a heart attack, stroke, or hospitalization for heart failure in the past 30 days - You have another condition that is the primary cause of your breathlessness - You are scheduled for heart or artery surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALAerobic Training

Aerobic training will be conducted at 30 minutes 3 times a week using brisk walking with target heart rates goals based on percentage of peak HR reserve (HRR= peak-rest HR) during baseline exercise right heart catheterization (RHC). The target HR will progress over the study period from 50% to 70% of peak HR reserve added to resting HR using the standard Karvonen formula (Goal HR = rest HR + target % of HRR). HR will be monitored using Fitbits to guide training intensity with raw data analyzed using the Fitabase platform to monitor compliance

BEHAVIORALLeg Training

Leg training will be performed using assigned ankle weights to perform knee extension while seated. Initial weight assignment will be guided by a protocol driven in-person exercise tolerance test using varying weights to identify the optimal initial and target training weight for each patient based on the 10 repetition maximum weight identified during this test. Leg training weight will begin at 40% of the baseline 10-repetition maximum weight for weeks 1-4 during which time patients will be required to complete 3 sets of 10 repetitions (30 repetitions total) on 3 days per week. For weeks 4-8, 55% of the initial 10-repetition maximum weight will be used for 4 sets of 10 repetitions (40 repetitions total). For weeks 8-12, 70% of the initial 10-repetition maximum weight will be used for 5 sets of 10 repetitions (50 repetitions total).