Gut Oxalate Absorption in Calcium Oxalate Stone Disease
Gastrointestinal Oxalate Absorption in Calcium Oxalate Stone Disease
University of Alabama at Birmingham
80 participants
Apr 17, 2024
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased absorption of dietary oxalate, which would lead to increased urinary excretion of oxalate. The study will recruit adult patients with a history of calcium oxalate kidney stones and healthy volunteers without kidney stones. Participants will * ingest fixed diets containing low and moderately high amounts of oxalate for 5 days at a time * ingest a soluble form of oxalate and sugar preparations to test gut permeability * collect urine, blood, stool and breath sample during the fixed diets and the soluble oxalate test
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
4 days of fixed eucaloric diet with low oxalate (\<60 mg/day), normal calcium content (600-1000 mg/day)
4 days of fixed eucaloric diet with moderately high oxalate (250-300 mg/day), normal calcium content (600-1000 mg/day)
Oral ingestion of 13C2-oxalate and sucralose.
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06331546