COOL-IT-PRO: Cryoablation of Breast Cancer in Non-surgical Patients

This study (COOL-IT-PRO) is investigating the use of cryoablation — a procedure that uses extreme cold to destroy cancer tissue — as a treatment for breast cancer in patients who are not able to have or have chosen not to have surgery. Cryoablation is guided by ultrasound and done without general anesthesia, making it an option for people for whom traditional surgery is not suitable. The study aims to assess how well this approach controls the cancer. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with breast cancer - Your tumor is visible on ultrasound and is more than 5mm from the skin surface - You are not undergoing surgery for one of the following reasons: you have a medical condition that makes sedation or anesthesia unsafe, your disease is unresectable or metastatic, your doctor has determined surgery is not indicated for another reason, or you have personally declined surgery - You are willing to sign informed consent **You may NOT be eligible if...** - You are able to have surgery and have not declined it - Your tumor cannot be seen clearly on ultrasound or is too close to the skin - You are under 18 years old Talk to your doctor to see if this trial is right for you.