RecruitingNCT05977712

Circadian Rhythm and Other Factors in Memory Clinic Patients

Circadian Rhythm and Other Individual Factors Among Memory Clinic Patients

Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

1,200 participants

Start Date

Mar 6, 2024

Study Type

OBSERVATIONAL

Conditions

Dementia

Summary

The CIRCAME study is a bicentric study of patients from 2 memory clinics in Paris. The main objective is to identify circadian rhythm components and other individual risk factors (sociodemographic, behavioral, and health related factors) associated with the diagnosis of subtypes (AD, Lewy bodies, vascular, frontotemporal dementia) and stages (cognitively healthy, mild cognitive impairment, clinical dementia) of dementia, independent of known risk factors (sociodemographic and genetic) and assess the relevance of use of these factors in primary care for screen of dementia including subtypes and stages. A secondary objective is to determine factors associated with progression of the disease, in terms of cognitive decline and limitations in activities of daily living, as well as progression to dementia among cognitively healthy controls and patients with mild cognitive impairment, up to 15 years after the inclusion period.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Patient of legal age (18 or over)
Signed informed consent form
Patient affiliated to the french social security system

Exclusion Criteria4

Skin allergy to plastic
Diagnosis of psychiatric disorder that can explain all cognitive symptoms
Inability to come accompanied for patients with a Mini-Mental State Examination (MMSE) cognitive score ≤18 or a clinician assessment indicating the need to be accompanied (e.g. wheelchair use, agitation)
Participation at the time of inclusion and during the 9-day period of wearing the accelerometer in interventional research with potential impact on circadian rhythm

Interventions

OTHERQuestionnaire

The questionnaire includes information on socio-demographics (age, sex, education, occupation, marital status), behavioural (smoking, alcohol consumption, social functioning), and health-related factors (morbidities, treatment, sleep disturbance, eye diseases, frailty, falls).

OTHERClinical examination

This includes earing test, cognitive tests (mini-mental status examination, MemScreen), body mass index, waist circumference, blood pressure and blood tests (biomarkers of Alzheimer's disease, neurodegeneration, and other dementias).

OTHERAccelerometer port

Participants will be wearing an accelerometer for 9 days.

OTHEREye examination

Eye fundus photo, OCT and OCT-A exams

OTHEREar Examination

Otoscopic examination, Wideband tympanometry, Pure-tone and speech audiometry (in quiet and in noise), Auditory evoked potentials, Electroencephalogram with auditory stimulation