Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement Study
Impact of a Novel HIV Peer Navigation and Overdose Prevention Intervention on Engagement in the HIV Prevention and Treatment Cascade
Johns Hopkins Bloomberg School of Public Health
500 participants
Jul 28, 2023
INTERVENTIONAL
Conditions
Summary
Through the proposed Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement (SCOPE) study, the investigators will design and evaluate an overdose prevention and HIV prevention study among people who use drugs (PWUD). Specifically, SCOPE will provide access to drug-checking services for PWUD to better understand the contents of the drug supply, in combination with PrEP for those who are HIV-, to both reduce overdose and HIV among PWUD in Baltimore City.
Eligibility
Inclusion Criteria9
- years or older,
- self-reports having used illicit stimulants or opioids at least once in the past 3 months,
- self-reports being HIV negative
- reports injection drug use in the past 6 months OR reports at least one of the following indicators of sexual HIV risk exposure in the past 6 months:
- Sexually Transmitted Infection (STI) diagnosis in the past 6 months
- "Condom-less" vaginal or anal sex in the past 6 months
- Willing to provide a urine sample for urine drug screening of substances
- Willing to undergo rapid HIV testing
- Willing to undergo STI testing
Exclusion Criteria3
- Determined to be too high or drunk or cognitively impaired, less than 18 years of age
- unwilling to provide all required biological specimens (Phase 3 only)
- unwilling/unable to give consent
Interventions
Participants will not be assigned to the intervention as it will be available to everyone. Check it will be a van-based HIV- and overdose-prevention program offered in the four areas of Baltimore city from which study participants are recruited. Intervention services will include point-of-care drug checking and PrEP assessment, prescription, and management, and they will be available to everyone, regardless of whether they are part of the SCOPE study cohort or not. Individual-level service usage data collected by intervention staff will not be considered in analysis of outcomes. However, study participants will self-report Check it utilization on the internally-developed surveys at 6, 12, and 18 months.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05977881