RecruitingNot ApplicableNCT05977881

Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement Study

Impact of a Novel HIV Peer Navigation and Overdose Prevention Intervention on Engagement in the HIV Prevention and Treatment Cascade

Sponsor

Johns Hopkins Bloomberg School of Public Health

Enrollment

500 participants

Start Date

Jul 28, 2023

Study Type

INTERVENTIONAL

Conditions

HIV Infections

Summary

Through the proposed Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement (SCOPE) study, the investigators will design and evaluate an overdose prevention and HIV prevention study among people who use drugs (PWUD). Specifically, SCOPE will provide access to drug-checking services for PWUD to better understand the contents of the drug supply, in combination with PrEP for those who are HIV-, to both reduce overdose and HIV among PWUD in Baltimore City.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study combines two services in a single outreach program: drug checking (testing street drugs for dangerous adulterants like fentanyl) and PrEP engagement (offering HIV prevention medication). The goal is to reach people who use illicit stimulants or opioids and reduce their risk of HIV. **You may be eligible if...** - You are 18 or older - You have used illicit stimulants (e.g., cocaine, methamphetamine) or opioids at least once in the past 3 months - You consider yourself HIV-negative - You inject drugs, or you have had unprotected sex or an STI diagnosis in the past 6 months - You are willing to provide a urine sample and undergo rapid HIV and STI testing **You may NOT be eligible if...** - You appear intoxicated or cognitively impaired at the time of the visit - You are unwilling to provide the required biological samples - You are under 18 Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERCHECKIT!

Participants will not be assigned to the intervention as it will be available to everyone. Check it will be a van-based HIV- and overdose-prevention program offered in the four areas of Baltimore city from which study participants are recruited. Intervention services will include point-of-care drug checking and PrEP assessment, prescription, and management, and they will be available to everyone, regardless of whether they are part of the SCOPE study cohort or not. Individual-level service usage data collected by intervention staff will not be considered in analysis of outcomes. However, study participants will self-report Check it utilization on the internally-developed surveys at 6, 12, and 18 months.