Phase III Trial of Concurrent Chemotherapy Alone in Patients With Low-risk Nasopharyngeal Carcinoma

This study is investigating whether chemotherapy alone — without the usual addition of radiation — is enough to treat certain patients with low-risk nasopharyngeal carcinoma (a type of cancer in the back of the nose and throat). The goal is to reduce treatment side effects while maintaining effectiveness. **You may be eligible if:** - You are 18–70 years old - You have a newly diagnosed, confirmed nasopharyngeal cancer of a specific tissue type - Your cancer is at stage III–IVa (but not the most advanced substages) - Your EBV virus levels in the blood are below 4,000 copies/mL - You are male, or a female who is not pregnant - Your blood counts, liver, and kidney function are within acceptable ranges **You may NOT be eligible if:** - Your cancer has spread to distant parts of the body - You have a different tissue type of nasopharyngeal cancer (keratinizing or basaloid type) - You have already received radiation, chemotherapy, or surgery for this cancer - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.