RecruitingNot ApplicableNCT05984524

Gamma-Music Based Intervention for Mild Alzheimer's Disease


Sponsor

Northeastern University

Enrollment

60 participants

Start Date

Jul 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The study will test and refine a novel brain-stimulation tool using gamma-frequency lights coupled with self-selected music for a gamma-music-based intervention for participants with mild Alzheimer's Disease. Results will yield a gamma-stimulation protocol that reliably influences brain activity (Aim 1), is adaptive, motivating and rewarding to use (Aim 2), and will generate predictions as to who might benefit the most from gamma-MBI (Aim 3). By bridging the gap between neurostimulation and behavioral intervention by combining music therapy with gamma- band neurostimulation, the present project aims to find a sustainable intervention that delays the progression of AD.


Eligibility

Min Age: 50 YearsMax Age: 95 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of gamma frequency sensory stimulation (flickering light and sound at 40 Hz) paired with music to see whether it can slow cognitive decline in people with mild Alzheimer's disease. This non-drug brain stimulation approach aims to strengthen brain rhythms associated with memory and attention. **You may be eligible if:** - You are 55–90 years old - You have a diagnosis of mild Alzheimer's disease with memory problems - Your MMSE score is between 20 and 24 (mild impairment range) - You test positive for amyloid (a key Alzheimer's protein) on a blood test - You have a study partner who spends time with you regularly - You are medically stable and on stable doses of any memory medications for at least 3 months **You may NOT be eligible if:** - You have had a stroke, or have significant vascular contributions to your memory problems - You have severe depression, substance abuse, or significant psychiatric history - You have hearing loss that cannot be corrected - You have any reason you cannot have an MRI scan Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALGamma-Music Based Intervention

Gamma or Control lights with Music-Based Intervention for 8 week period


Locations(1)

Northeastern University

Boston, Massachusetts, United States

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NCT05984524


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