RecruitingPhase 1Phase 2NCT05988632

Intranasal Insulin for Treatment of Alcohol Use Disorder

Sponsor

Brown University

Enrollment

40 participants

Start Date

Feb 25, 2025

Study Type

INTERVENTIONAL

Conditions

Alcohol Use Disorder

Summary

This is a randomized controlled trial (RCT), within-subject, crossover, double-blind, placebo-controlled in non-treatment-seeking individuals with Alcohol Use Disorder (AUD) (N=40, 50% female) randomized to IN insulin or placebo. In a bar laboratory setting, randomized participants will receive a single dose of IN insulin (80IU) or an IN matched placebo (0.9% Saline). Participants will undergo a cue-reactivity paradigm followed by an alcohol challenge that includes an alcohol drink designed to raise the breath alcohol content (BrAC) to 0.08g/dL.

Eligibility

Min Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Placebo then Regular Human Insulin and a drug called Regular Human Insulin then Placebo for people with alcohol use disorder. The study is currently recruiting participants at 1 location. People eligible for this study include aged 21 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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