Multi-modular Chimeric Antigen Receptor Targeting GD2 in Neuroblastoma
University College, London
12 participants
Apr 19, 2024
INTERVENTIONAL
Conditions
Summary
MAGNETO is a single-centre, non-randomised, open label Phase I clinical trial of an Advanced Therapy Investigational Medicinal Product (ATIMP) in children and teenagers aged 1-16 years with relapsed or refractory neuroblastoma. The study will assess the feasibility of generating the ATIMP (GD2 CAR T cells) and the safety of administering the ATIMP in patients with relapsed or refractory neuroblastoma.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
The GD2 CAR T cells target GD2 positive cells. The cells also express transgenes that aim to increase their resistance within the tumour microenvironment.
Locations(1)
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NCT05990751