RecruitingPhase 1NCT05990751

Multi-modular Chimeric Antigen Receptor Targeting GD2 in Neuroblastoma


Sponsor

University College, London

Enrollment

12 participants

Start Date

Apr 19, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

MAGNETO is a single-centre, non-randomised, open label Phase I clinical trial of an Advanced Therapy Investigational Medicinal Product (ATIMP) in children and teenagers aged 1-16 years with relapsed or refractory neuroblastoma. The study will assess the feasibility of generating the ATIMP (GD2 CAR T cells) and the safety of administering the ATIMP in patients with relapsed or refractory neuroblastoma.


Eligibility

Min Age: 1 YearMax Age: 16 Years

Plain Language Summary

Simplified for easier understanding

This study tests a new type of CAR T-cell therapy — genetically engineered immune cells that target a protein called GD2 found on neuroblastoma cells — in children with neuroblastoma whose cancer has come back or has not responded to prior treatment. **You may be eligible if...** - You are between 1 and 16 years old - You have a confirmed diagnosis of neuroblastoma - Your cancer has relapsed or is resistant to at least one prior treatment regimen - You have measurable disease that can be assessed on scans **You may NOT be eligible if...** - You are outside the 1-16 age range - Your neuroblastoma has not been previously treated - You do not have measurable disease at the time of enrollment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALGD2 CAR T cells

The GD2 CAR T cells target GD2 positive cells. The cells also express transgenes that aim to increase their resistance within the tumour microenvironment.


Locations(1)

Great Ormond Street Hospital

London, United Kingdom

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NCT05990751


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