Neoadjuvant Radiotherapy and Immediate Implant-Based Breast Reconstruction

This study is exploring whether radiation therapy can be given before mastectomy (breast removal surgery) instead of after, and whether this timing is safe when combined with breast reconstruction using an implant placed at the same time as the surgery. **You may be eligible if...** - You are a woman over 18 years old - You have been diagnosed with breast cancer confirmed by a biopsy - You need to have a mastectomy - You are expected to need radiation therapy - You plan to have breast reconstruction using an implant **You may NOT be eligible if...** - You have had a previous breast cancer or another cancer that required breast/underarm radiation - You are unable to give informed consent - Your medical team cannot determine whether radiation is needed before surgery Talk to your doctor to see if this trial is right for you.