RecruitingNot ApplicableNCT05994170

Reducing High Risk Primary Tumor Clinical Target Volumes (CTVp1) in Non-metastatic Nasopharyngeal Carcinoma

Reducing High Risk Primary Tumor Clinical Target Volumes (CTVp1) in Non-metastatic Nasopharyngeal Carcinoma Treated With Intensity-modulated Radiotherapy(IMRT): A Phase 3, Multicentre, Randomised Controlled Trial(CTVp1-NPC)


Sponsor

Zhongshan People's Hospital, Guangdong, China

Enrollment

454 participants

Start Date

Aug 4, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

To evaluate the long-term local control, survival rate, acute and late radiation related toxicities, quality of life after reducing high risk primary tumor clinical target volumes (CTVp1) in non-metastatic nasopharyngeal carcinoma treated with IMRT.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether it is safe to use a smaller radiation treatment zone for people with nasopharyngeal carcinoma (a cancer at the back of the nasal cavity). Reducing the radiation area could lower side effects while still effectively treating the cancer. **You may be eligible if...** - You have a confirmed diagnosis of nasopharyngeal carcinoma (a specific type) - Your cancer is newly diagnosed and has not been treated before - Your tumor is contained on one side of the nasopharynx and does not cross the midline - Your cancer is Stage I through IVa **You may NOT be eligible if...** - Your tumor crosses to both sides of the nasopharynx - You have previously received treatment for this cancer - Your cancer is a different type or stage not covered by the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONReduction CTVp1

High Risk Primary Tumor Clinical Target Volumes (CTVp1) is defined as 5mm margin from GTVp,including pre-induction chemotherapy tumor extension( CTVp1=GTVp+5mm)

RADIATIONNon-reduction CTVp1

High Risk Primary Tumor Clinical Target Volumes (CTVp1) is defined as whole nasopharynx as well as 5mm margin from GTVp( CTVp1=GTVp+5mm+whole nasopharynx)


Locations(1)

Zhongshan City People's Hospital

Zhongshan, Guangdong, China

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NCT05994170


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