Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy

This study is using a special imaging technique to measure oxygen levels inside tumors (tumor hypoxia — areas of the tumor that lack oxygen), and then using that information to customize radiation therapy for head and neck cancer or brain metastases. Tumors with low oxygen are harder to treat, so targeting those areas with higher doses may improve outcomes. **You may be eligible if...** - You have head and neck squamous cell carcinoma or brain metastases confirmed by a pathology test or clinical diagnosis - You have at least one measurable tumor - You are in good overall health (ECOG 0–1 or Karnofsky score ≥70%) - Your life expectancy is at least 6 months **You may NOT be eligible if...** - You are in poor health - Your tumor cannot be measured on a scan - You are pregnant or may become pregnant (due to radiation risks) Talk to your doctor to see if this trial is right for you.