A Prospective Cohort Study of Myasthenia Gravis in China
Clinical Characteristics, Prognosis and Biomarkers of Myasthenia Gravis: a Prospective Cohort Study in China
Peking Union Medical College Hospital
202 participants
Aug 20, 2023
OBSERVATIONAL
Conditions
Summary
The goal of this prospective cohort study is to investigate long-term therapeutic strategies for myasthenia gravis (MG) and identify potential biomarkers. The main questions it aims to answer are: 1. Whether low-dose oral steroids may lead to a reduction in the recurrence rate among patients with MG. 2. To identify potential biomarkers that can predict disease progression and prognosis. This study recruits well-controlled patients with MG. Based on patient preferences and considerations such as coexisting conditions (e.g., uncontrolled hypertension, diabetes, severe osteoporosis, obesity), the participants will be non-randomly divided into two groups: a maintenance steroid therapy group and a withdrawal group (withdraw all immunosuppresants). Subsequently, these groups of patients will undergo long-term follow-up assessments.
Eligibility
Inclusion Criteria4
- : Attended the outpatient department of neurology of PUMCH from 9/30/2022 to 9/30/2024.
- : Diagnosed as myasthenia gravis.
- : Follow-up time at PUMCH>6 months.
- : The patient understood and signed the informed consent form.
Exclusion Criteria2
- : Comorbidities with other conditions that cause skeletal muscle weakness make the clinical symptoms difficult to assess
- : Records related to comorbidities and medications were not available at baseline and during follow-up.
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Interventions
Maintaining low-dose oral steroids
Withdraw all immunosuppresants
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06006832