Platform Trial to Assess the Efficacy of Multiple Drugs in Amyotrophic Lateral Sclerosis (ALS)

This is a platform trial testing multiple experimental drugs for people with ALS (also known as Lou Gehrig's disease), a condition that gradually weakens the muscles. A platform trial means different drugs can be tested at the same time within the same study framework. **You may be eligible if...** - You are 18 or older - You have been diagnosed with ALS based on established clinical criteria - Your disease is at a moderate progression level (as measured by a standard ALS risk score) - You are willing and able to use contraception during and after the trial if you can have children - You are currently taking riluzole (a common ALS medication) at a stable dose, or have stopped it at least 30 days ago **You may NOT be eligible if...** - Your ALS is very mild or very advanced (outside the specified risk profile) - You are pregnant or planning to become pregnant - You are currently breastfeeding - You are unable to complete study visits and procedures Talk to your doctor to see if this trial is right for you.