RecruitingPhase 2NCT06008730

Proton Beam Radiation Therapy After Treatment for Resected N2 Non-Small Cell Lung Cancer

Proton Beam Radiation Therapy in Patients With Resected N2 Non-Small Cell Lung Cancer

Sponsor

Emory University

Enrollment

20 participants

Start Date

Dec 13, 2024

Study Type

INTERVENTIONAL

Conditions

Resectable Lung Non-Small Cell Carcinoma

Summary

This clinical trial tests proton beam radiation therapy in patients with non-small cell lung cancer who have undergone surgical resection and have lymph nodes involving the middle of the chest. Proton therapy is a type of radiation treatment that kills cancer cells while avoiding surrounding healthy tissue. Proton beam therapy is sometimes used after cancer surgery to reduce the risk of cancer recurrence (coming back). Giving proton beam radiation therapy may work better than conventional radiation treatment after surgery in patients with non-small cell lung cancer.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying whether proton beam radiation therapy (a precise form of radiation) after surgery can improve outcomes for patients with non-small cell lung cancer (NSCLC) that had spread to lymph nodes in the chest (called N2 disease) and was treated with pre-surgery therapy. **You may be eligible if...** - You are 18 or older - You had surgery (lobectomy or pneumonectomy) after pre-operative treatment for NSCLC - Surgical pathology confirmed your cancer was completely removed AND involved at least one mediastinal (chest) lymph node - You are in reasonably good health (ECOG 0–2) - Your blood counts and kidney function are within acceptable ranges **You may NOT be eligible if...** - Your surgery did not fully remove the cancer (incomplete resection) - Your cancer spread to the highest mediastinal lymph node sampled - You are pregnant or breastfeeding - Your blood counts are too low at the time of enrollment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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