RecruitingPhase 2NCT06775275

A Study of Adebrelimab in Combination with Chemo with or Without Bevacizumab Neoadjuvant Therapy for Resectable NSCLC

A Randomized Phase II Study of Adebrelimab in Combination with Chemotherapy with or Without Bevacizumab Neoadjuvant Therapy for Resectable Non-Squamous Non-Small Cell Lung Cancer


Sponsor

The First Affiliated Hospital of Guangzhou Medical University

Enrollment

60 participants

Start Date

Sep 24, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This is a prospective, multicenter, randomized, uncontrolled Phase II study to assess the efficacy and safety of adebrelimab in combination with chemotherapy with or without bevacizumab for the treatment of resectable Stage II-IIIB (T3N2) NSQ-NSCLC and to explore biomarkers associated with efficacy.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether adding an immunotherapy drug called adebrelimab — with or without a blood vessel–blocking drug (bevacizumab) — to standard chemotherapy before surgery helps shrink tumors more effectively in people with resectable non-squamous non-small cell lung cancer (a common type of lung cancer that can be surgically removed). **You may be eligible if...** - You are between 18 and 65 years old - You have non-squamous NSCLC that is suitable for surgery - You have not yet received any treatment for this cancer (surgery, chemo, radiation, or biologics) - You are in good general health (ECOG 0–1) with adequate lung function **You may NOT be eligible if...** - You have squamous cell lung cancer or small cell lung cancer - You have previously used immunotherapy (anti-PD1, anti-PDL1, anti-CTLA4) or anti-angiogenic drugs - You have a known allergy to the study drugs - You have severe uncontrolled health conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAdebellizumab

adebrelimab

DRUGBevacizumab

bevacizumab

DRUGPlatinum-based chemotherapy

paclitaxel or albuminotaxol or docetaxel combined with platinum, pemetrexed combined with platinum. Platinums include carboplatin, cisplatin and nedaplatin.


Locations(1)

Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, China

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NCT06775275


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