A Clinical Research About CD70-targeted CAR-T in the Treatment of CD70-positive Advanced/Metastatic Solid Tumors

This trial is testing a CAR-T cell therapy that targets a protein called CD70, found on some solid tumors. Like other CAR-T treatments, the patient's own immune cells are modified in a lab to seek out and destroy cancer cells expressing CD70. **You may be eligible if...** - You are 18 or older - You have confirmed advanced or metastatic solid tumor that tests CD70-positive (strong expression, 3+) - Your cancer has not responded to or progressed through standard treatments including targeted therapy and anti-cancer drugs - You have at least one measurable tumor on imaging - You are in reasonably good health (ECOG 0–2) with a life expectancy over 12 weeks - Your heart, kidney, liver, and blood counts are within acceptable ranges **You may NOT be eligible if...** - Your tumor is CD70-negative - You have serious untreated mental illness - Your organ function is significantly impaired - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.