Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome
Effect of Volatile Sedation on Spontaneous Breathing During Mechanical Ventilation for Patients With the Acute Respiratory Distress Syndrome
Guy's and St Thomas' NHS Foundation Trust
20 participants
Nov 1, 2023
INTERVENTIONAL
Conditions
Summary
This study will investigate how different types of routine sedation may affect patient's breathing whilst on a ventilator in the Intensive Care Unit (ICU). There are different approaches to sedation which may have advantages and disadvantages. During the study patients will receive both intravenous and inhaled volatile sedation (similar to anaesthetic 'gases' used for general anaesthesia) and the drive to breath, breathing efforts and function of the lung will be assessed.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Standard care, propofol sedation - 2 hour periods of observation before and after inhaled volatile sedation
Inhaled volatile sedation for 6 hours - 2 hours wash in / wash out, followed by 4 hours of observations
Locations(1)
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NCT06014138