EGCG for Hepatocellular Carcinoma Chemoprevention

This trial is testing whether EGCG (epigallocatechin gallate, the main active compound in green tea) can prevent liver cancer (hepatocellular carcinoma) in adults with liver cirrhosis who are at high risk of developing it. Participants take EGCG supplements daily for several months. **You may be eligible if...** - You are 18 or older - You have a confirmed diagnosis of liver cirrhosis - Your liver is compensated (no active decompensation such as bleeding or severe fluid buildup) - You have never had liver cancer - You have a high-risk liver lesion profile (high FIB-4 score and high-risk precancerous liver score) - You are in reasonably good overall health (Karnofsky score ≥70) - You do not carry the HLA-B*35:01 genetic variant (associated with EGCG-related liver toxicity) **You may NOT be eligible if...** - You are currently using or have previously used EGCG supplements - You have had a bad reaction to green tea products - You are severely obese (BMI >40) - You are actively drinking alcohol - You developed liver cancer during the study Talk to your doctor to see if this trial is right for you.