RecruitingEarly Phase 1NCT06016465

Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?

Does Nerve Block Plus Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hours Better Than Nerve Block Alone?


Sponsor

Texas Tech University Health Sciences Center, El Paso

Enrollment

84 participants

Start Date

Sep 15, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief. Previous studies have demonstrated that adding steroids as an adjunct treatment to standard migraine treatment can reduce recurrence of headaches in the subsequent few days.


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Inclusion Criteria3

  • Meet ICHD-3 Migraine Headache Criteria
  • Had a minimum 5-point reduction in headache intensity after nerve block(s) or post- block pain score of 0 to 2
  • Nerve block performed with bupivacaine 0.5%

Exclusion Criteria8

  • Head trauma
  • Suspicion of secondary headache (i.e. stroke, known tumor, glaucoma)
  • Headache in the setting of viral syndrome
  • Chronically on steroids
  • Known allergy to dexamethasone
  • Unable to reach the patient by phone or text for follow-up
  • Gestational diabetes or other uncontrolled diabetes
  • Known to be immunocompromised

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Interventions

DRUGDexamethasone Oral

Two 4mg pills

DRUGPlacebo

2 placebo pills


Locations(1)

University Medical Center of El Paso

El Paso, Texas, United States

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NCT06016465


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