Migraine Clinical Trials

197 recruitingLast updated: June 18, 2026

There are 197 actively recruiting migraine clinical trials across 48 countries. Studies span Not Applicable, Phase 3, Phase 2, Phase 4, Early Phase 1, Phase 1. Top locations include Cincinnati, Ohio, United States, Madrid, Spain, Barcelona, Spain. Updated daily from ClinicalTrials.gov.


Migraine Trials at a Glance

197 actively recruiting trials for migraine are listed on ClinicalTrialsFinder across 6 cities in 48 countries. The largest study group is Not Applicable with 70 trials, with the heaviest enrollment activity in Cincinnati, Madrid, and Barcelona. Lead sponsors running migraine studies include AbbVie, Pfizer, and Children's Hospital Medical Center, Cincinnati.

Treatments under study

About Migraine Clinical Trials

Looking for clinical trials for Migraine? There are currently 137 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Migraine trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Migraine clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 197 trials

Recruiting
Not Applicable

Mind Body Balance for Pediatric Migraine

Migraine with auraMigraineChronic Migraine+5 more
Children's Hospital Medical Center, Cincinnati260 enrolled2 locationsNCT04715685
Recruiting
Not Applicable

Ultrasound Guided Infratemporal Sphenopalatine Ganglion Supravoltage Versus Standard Voltage Pulsed Radiofrequency for Pain Alleviation in Chronic Refractory Migraine.

Chronic Migraine, Headache
Minia University100 enrolled2 locationsNCT07500558
Recruiting
Phase 3

A Study of Eptinezumab in Pediatric Participants With Episodic Migraine

Episodic Migraine
H. Lundbeck A/S315 enrolled65 locationsNCT05897320
Recruiting
Not Applicable

BE WELL With Migraine: Brain Education and WELLness With Migraine

Migraine
Wake Forest University Health Sciences286 enrolled3 locationsNCT05987592
Recruiting
Phase 3

A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine

Chronic Migraine in Children
H. Lundbeck A/S285 enrolled84 locationsNCT04965675
Recruiting
Phase 3

A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine

Migraine
H. Lundbeck A/S600 enrolled70 locationsNCT05164172
Recruiting
Phase 3

A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine

Episodic Migraine
AbbVie450 enrolled98 locationsNCT05711394
Recruiting
Phase 3

A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine

Menstrual Migraine
Pfizer723 enrolled123 locationsNCT06641466
Recruiting

i-NEED: NEw migrainE Drugs Database

Chronic MigraineEpisodic MigraineMedication-overuse Headache
IRCCS San Raffaele Roma2,641 enrolled2 locationsNCT07103694
Recruiting

RimegepAnt effectIvenesS and tolErability as Migraine Preventive Treatment

Migraine with auraMigraineMigraine Without Aura
University of Florence100 enrolled2 locationsNCT06409832
Recruiting
Phase 3

A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine

Migraine
Pfizer200 enrolled103 locationsNCT06616194
Recruiting
Phase 1

A Study to Compare the Blood Levels of Two Dosage Formulations of the Study Medicine in Healthy Adults

Migraine
Pfizer36 enrolled1 locationNCT07594769
Recruiting
Not Applicable

MMA Embolization for Refractory Chronic Migraine

Migraine Disorders
Cerenovus, Part of DePuy Synthes Products, Inc.70 enrolled9 locationsNCT06735833
Recruiting
Phase 4

A Study to Learn About the Safety of Taking an Additional Dose of the Medicine Rimegepant in Adults With Migraine

Acute Treatment of Migraine
Pfizer400 enrolled3 locationsNCT07609914
Recruiting
Not Applicable

Supraspinal Processing of Sensory Aspects of Pain

Musculoskeletal PainFibromyalgiaFunctional Abdominal Pain Syndrome+2 more
Children's Hospital Medical Center, Cincinnati255 enrolled1 locationNCT05814497
Recruiting
Phase 3

Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine

Acute Treatment of Migraine
Pfizer600 enrolled126 locationsNCT04743141
Recruiting
Phase 3

Randomized Study in Children and Adolescents With Migraine: Acute Treatment

Pediatric Migraine
Pfizer2,100 enrolled246 locationsNCT04649242
Recruiting
Not Applicable

Determining the Utility of a Behavioral Intervention in Chronic Migraine

MigraineChronic MigraineLifestyle Factors+3 more
Mayo Clinic60 enrolled1 locationNCT05415020
Recruiting
Phase 3

Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects

Migraine
Pfizer640 enrolled91 locationsNCT05156398
Recruiting
Not Applicable

A Comprehensive Digital Care Program for Migraine Management

Migraine with auraMigraineMigraine Without Aura
Hinge Health, Inc140 enrolled1 locationNCT07642414