Migraine Clinical Trials

124 recruiting

Migraine Trials at a Glance

168 actively recruiting trials for migraine are listed on ClinicalTrialsFinder across 6 cities in 46 countries. The largest study group is Not Applicable with 52 trials, with the heaviest enrollment activity in Cincinnati, Madrid, and Pavia. Lead sponsors running migraine studies include AbbVie, Pfizer, and Children's Hospital Medical Center, Cincinnati.

Treatments under study

About Migraine Clinical Trials

Looking for clinical trials for Migraine? There are currently 124 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Migraine trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Migraine clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 168 trials

Recruiting

NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

MigraineMajor DepressionBipolar Disorder
National Institute of Mental Health (NIMH)1,260 enrolled1 locationNCT05669703
Recruiting
Not Applicable

Aerobic Exercise and Its Impact on Sensory, Musculoskeletal, and Psychosocial Aspects in Migraine

MigraineHeadacheMigraine Disease+2 more
University of Sao Paulo100 enrolled1 locationNCT06716489
Recruiting
Not Applicable

BE WELL With Migraine: Brain Education and WELLness With Migraine

Migraine
Wake Forest University Health Sciences286 enrolled3 locationsNCT05987592
Recruiting

Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics

Healthy VolunteerTobacco Use DisorderMigraine+7 more
Yale University200 enrolled2 locationsNCT06624137
Recruiting
Phase 2

Cannabis for the Prophylactic Treatment of Migraine

Chronic Migraine
University of Calgary72 enrolled1 locationNCT03972124
Recruiting
Phase 3

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine

Episodic Migraine
Merz Therapeutics GmbH990 enrolled106 locationsNCT07018700
Recruiting
Phase 3

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine

Chronic Migraine
Merz Therapeutics GmbH780 enrolled106 locationsNCT07018713
Recruiting
Phase 2

Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial Pain

MigraineCluster HeadacheCraniofacial Pain+3 more
Stanford University15 enrolled1 locationNCT04930887
Recruiting
Phase 3

Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine

Acute Treatment of Migraine
Pfizer600 enrolled126 locationsNCT04743141
Recruiting
Phase 3

Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects

Migraine
Pfizer640 enrolled90 locationsNCT05156398
Recruiting
Phase 3

Randomized Study in Children and Adolescents With Migraine: Acute Treatment

Pediatric Migraine
Pfizer2,100 enrolled246 locationsNCT04649242
Recruiting
Phase 3

A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine

Menstrual Migraine
Pfizer723 enrolled122 locationsNCT06641466
Recruiting
Not Applicable

MMA Embolization for Refractory Chronic Migraine

Migraine
Cerenovus, Part of DePuy Synthes Products, Inc.70 enrolled9 locationsNCT06735833
Recruiting
Phase 3

A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years

Chronic Migraine
AbbVie420 enrolled61 locationsNCT06810505
Recruiting

External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy

PregnancyDepressionAnxiety+3 more
Cefaly Technology550 enrolled1 locationNCT06788977
Recruiting
Phase 3

A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine

Migraine
H. Lundbeck A/S600 enrolled70 locationsNCT05164172
Recruiting
Phase 3

Study of Oral Atogepant Tablets to Assess Safety and Efficacy in Adult Participants With Migraine

Migraine
AbbVie1,300 enrolled149 locationsNCT06241313
Recruiting
Phase 3

A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine

Migraine
Pfizer200 enrolled107 locationsNCT06616194
Recruiting
Not Applicable

New Methods for Evaluating Preventive Migraine Treatment

MigraineHeadache DisordersChronic Migraine, Headache+1 more
University of Aarhus60 enrolled2 locationsNCT07071506
Recruiting

Genetic and Biohumoral Factors Involved in Menière's Disease and Their Correlation With Phenotypes

Meniere's DiseaseVertigoVestibular Migraine
IRCCS San Raffaele250 enrolled1 locationNCT07518069