RecruitingNCT06023225

Sex Hormones, Postoperative Pain and Opioid Use

Relationship Between Sex Hormones, Postoperative Pain and Opioid Use: the Role of Immune Factors

Sponsor

Washington University School of Medicine

Enrollment

210 participants

Start Date

Sep 1, 2023

Study Type

OBSERVATIONAL

Conditions

Opioid Use Postoperative Pain

Summary

Aim 1- To identify relationships between sex hormone levels and postoperative pain and opioid use. Aim 2: To determine whether the effects of testosterone on postoperative pain and opioid use are mediated by immune factors

Eligibility

Sex: FEMALEMin Age: 11 YearsMax Age: 16 Years

Inclusion Criteria1

Pediatric female patients between the ages 11-16 undergoing an orthopedic (trauma and non-trauma) surgical procedure involving a long bone or joint, or the spine, English speaking

Exclusion Criteria1

Pregnancy; Diagnosis of chronic pain, Psychiatric, developmental or neurological disorders, Disorders that are associated with pubertal maturation (e.g., precocious puberty).

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Interventions

BEHAVIORALPain

Postoperative pain levels

BEHAVIORALOpioid use

Postoperative opioid use

Locations(1)

Washington University School of Medicine

St Louis, Missouri, United States

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NCT06023225

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