Postoperative Pain Clinical Trials

264 recruitingLast updated: June 17, 2026

There are 264 actively recruiting postoperative pain clinical trials across 36 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 3, Phase 1. Top locations include Cairo, Egypt, Istanbul, Turkey (Türkiye), Konya, Turkey (Türkiye). Updated daily from ClinicalTrials.gov.


Postoperative Pain Trials at a Glance

264 actively recruiting trials for postoperative pain are listed on ClinicalTrialsFinder across 6 cities in 36 countries. The largest study group is Not Applicable with 162 trials, with the heaviest enrollment activity in Cairo, Istanbul, and Konya. Lead sponsors running postoperative pain studies include Cairo University, Bursa City Hospital, and General Hospital of Ningxia Medical University.

Browse postoperative pain trials by phase

Treatments under study

About Postoperative Pain Clinical Trials

Looking for clinical trials for Postoperative Pain? There are currently 181 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Postoperative Pain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Postoperative Pain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 264 trials

Recruiting
Phase 4

Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair

Opioid UsePostoperative PainAnesthesia+5 more
University of Crete40 enrolled1 locationNCT04894864
Recruiting
Phase 4

Comparison of Intraperitoneal Bupivacaine and Saline Irrigation for Pain Relief After Laparoscopic Cholecystectomy

Postoperative Pain
Wah Medical college , POF hospital106 enrolled1 locationNCT07650760
Recruiting

Effect of Bilateral Ultrasound-Guided TAP Block on Quality of Recovery in Cesarean Delivery Patients Receiving Intrathecal Morphine

Postoperative Pain ManagementObstetric AnesthesiaRecovery From Anesthesia
MEHMET GÖKHAN TAFLAN150 enrolled1 locationNCT07145619
Recruiting
Not Applicable

Effectiveness of Thoracoabdominal Nerve Block (M-TAPA) on Postoperative Pain Relief in Laparoscopic Hysterectomy

Postoperative PainHysterectomyPlane Blocks
Istinye University60 enrolled1 locationNCT07483190
Recruiting
Not Applicable

Rectus-Intercostal Fascial Plane Block for Liver Transplantation Donors

Postoperative PainLiver TransplantationLiving Donor
Istinye University64 enrolled1 locationNCT07233096
Recruiting
Not Applicable

Analgesic Efficacy of Fascia Iliaca Compartment Block Compared With Intrathecal Nalbuphine for Hip Surgery Under Spinal Anesthesia

Postoperative Pain
Ain Shams University120 enrolled1 locationNCT06818396
Recruiting
Not Applicable

The Effect of Intravenous Dexketoprofen on the Severity and Incidence of Rebound Pain

Pain ManagementPostoperative PainRebound Pain+1 more
Eskisehir Osmangazi University66 enrolled1 locationNCT07642674
Recruiting
Not Applicable

EFFECT OF NITI SYSTEMS AND XP-ENDO FINISHER ON POSTOPERATIVE PAIN

Postoperative Pain After Endodontic Treatment
BUSRA OZTURK80 enrolled2 locationsNCT07642596
Recruiting
Not Applicable

Biceps Femoris Short Head (BiFeS) Block and Adductor Canal Block for Postoperative Analgesia Following Total Knee Arthroplasty

Total Knee ArthroplastyPostoperative Pain Following Knee Arthroplasty
Ömer Kayar60 enrolled1 locationNCT07577869
Recruiting
Not Applicable

Acupuncture for Pain Control After Ambulatory Knee Arthroscopy

Postoperative Pain; Knee Arthroscopy; Acupuncture
University Medicine Greifswald60 enrolled1 locationNCT04134702
Recruiting

ESP Block vs. EXORA Block for Postoperative Pain in Nephrectomy

Postoperative PainNephrectomy
Bakirkoy Dr. Sadi Konuk Research and Training Hospital84 enrolled1 locationNCT07640282
Recruiting

Ultrasound-Guided Transversus Abdominis Plane Block Versus Epidural Block for Umbilical Hernia Analgesia

Umbilical herniaPostoperative Pain Management
Sakarya University30 enrolled1 locationNCT07327463
Recruiting
Phase 2

Impact of RADA16 Use on Outcomes Following Tonsillectomy in Children

Postoperative Pain
Rutgers, The State University of New Jersey134 enrolled2 locationsNCT07188779
Recruiting
Not Applicable

Transauricular Vagus Nerve Stimulation Frequencies for Postoperative Pain

Postoperative PainOpioid Consumption, PostoperativePostoperative Nausea and Vomiting (PONV)
Federal University of Bahia174 enrolled1 locationNCT07633444
Recruiting
Phase 3

RADA16 for Adult Tonsillectomy

Postoperative Pain
Rutgers, The State University of New Jersey134 enrolled2 locationsNCT07060495
Recruiting
Not Applicable

EOIB for Pain After Laparoscopic Cholecystectomy

Postoperative PainLaparoscopic Cholecystectomy
Shiyou Wei56 enrolled1 locationNCT07332546
Recruiting
Not Applicable

Comparison of IV Analgesia Protocols After the Regional Block's Effect Diminishes in Thoracic Surgery

Postoperative PainThoracic Surgery, Video-assistedPatient-controlled Analgesia+2 more
Ankara Etlik City Hospital135 enrolled1 locationNCT07610408
Recruiting

Cardiac Surgery, the Incidence and Impact of Chronic postOperative Pain: a Survey

Cardiac SurgeryChronic Postoperative Pain
Universitaire Ziekenhuizen KU Leuven1,000 enrolled1 locationNCT07640646
Recruiting
Not Applicable

Postoperative Cryocuff vs. Conventional Icepack in TKA - What is More Effective in Reducing Pain and Swelling?

Postoperative Swelling After TKAPostoperative Pain After Tka
Prof. Dr. med. Andreas Halder102 enrolled1 locationNCT07627854
Recruiting
Not Applicable

The Effectiveness of Quadro İliac Plane Block in Percutaneous Nephrolithotomies

Postoperative PainPercutaneous Nephrolithotomy
Cumhuriyet University60 enrolled1 locationNCT07203859