RecruitingNCT06025903

Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis


Sponsor

IRCCS San Raffaele

Enrollment

140 participants

Start Date

Sep 20, 2021

Study Type

OBSERVATIONAL

Conditions

Summary

The purpose of this project is to study genetic determinants of mitochondrial impairment in primary progressive multiple sclerosis. Specific aims are: 1) identify mitochondrial-related pathways, inherited and somatic mitochondrial DNA mutations associated to primary progressive multiple sclerosis, 2) functionally assess the identified genetic alterations.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether problems with energy-producing structures in cells called mitochondria play a role in primary progressive multiple sclerosis (PPMS) — a form of MS where symptoms gradually worsen from the start without relapses. Understanding this could lead to new treatments that protect nerve cells from damage. **You may be eligible if...** - You have been diagnosed with primary progressive multiple sclerosis (PPMS) or relapsing-remitting multiple sclerosis (RRMS) - You are able to give informed consent - You are 18 years of age or older **You may NOT be eligible if...** - You are under 18 years old - You do not have primary progressive or relapsing-remitting multiple sclerosis Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(2)

ASST della Valle Olona - Ospedale di Gallarate

Gallarate, VA, Italy

IRCCS San Raffaele

Milan, MI, Italy

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NCT06025903


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