Preliminary Efficacy of Different Exercise Training During Immunotherapy in Patients With Lung Cancer: The ENHANCE Trial

This trial (called ENHANCE) is studying whether adding structured exercise to immunotherapy treatment can improve outcomes for people with advanced non-small cell lung cancer. Participants who are not currently exercising much will be assigned to different types of exercise programs to see which type best supports their immune response and quality of life during treatment. **You may be eligible if...** - You are 18 or older with advanced non-small cell lung cancer - You are currently receiving immunotherapy (anti-PD-1 or anti-PD-L1 drugs) and plan to continue for at least 12 weeks - You exercise less than 60 minutes of moderate-to-vigorous activity per week - Your oncologist has cleared you for exercise - You can communicate and complete forms in English and can travel to Dana-Farber Cancer Institute **You may NOT be eligible if...** - You already exercise more than 60 minutes per week at moderate-to-vigorous intensity - You have unstable health conditions that make moderate exercise unsafe - You have developed a second cancer requiring concurrent treatment Talk to your doctor to see if this trial is right for you.