WMT for Autism Spectrum Disorder (ASD)
Washed Microbiota Transplantation (WMT) for Autism Spectrum Disorder (ASD)
The Second Hospital of Nanjing Medical University
80 participants
Sep 20, 2023
INTERVENTIONAL
Conditions
Summary
Autism Spectrum Disorder (ASD) is a group of serious neurodevelopmental disorders. A significant comorbidity exists between ADHD and ASD: 30%-50% of individuals with ASD exhibit ADHD symptoms, and two-thirds with ADHD show ASD traits. Intestinal microbial disturbance is common in children with ASD. A great deal of evidence shows that intestinal microbes can influence the brain to play its role through "gut-brain-microbiota axis". We intend to explore the role of Washed Microbiota Transplantation in improving symptoms of children in ASD with or without ADHD; To study the potential etiological mechanism of WMT for the neurodevelopmental disorders.
Eligibility
Inclusion Criteria3
- Children and adolescents with an established diagnosis of ADHD or ADHD + ASD according to the Diagnostic and Statistical Manual Of Mental Disorders Fifth Edition;.
- Age 3-17 years.
- Received stable treatments for ≥1 month preceding WMT
Exclusion Criteria5
- Their guardian could not understand the questionnaires or provide informed consent.
- Diagnosed with a single-gene disorder, major brain malformations, gastrointestinal diseases (ulcerative colitis, Crohn's disease, or eosinophilic esophagitis)
- Had severe comorbidities including cardiopulmonary failure, severe liver, and kidney diseases, severe infection, tumors, etc.
- Accompanied with other life-threatening disorders required emergency treatment.
- Unable to tolerate colonoscopy or anesthesia.
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Interventions
The prepared microbiota suspension was infused into the participates' lower gut.
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT06030752