RecruitingPhase 3NCT06031246

Selective Lymph Node Dissection for cT1N0M0 Invasive NSCLC With CTR>0.5 Located in the Apical Segment (ECTOP-1018)

Selective Lymph Node Dissection for cT1N0M0 Invasive Non-small Cell Lung Cancer With CTR>0.5 Located in the Apical Segment: a Single-arm, Multi-center, Phase III Trial

Sponsor

Fudan University

Enrollment

634 participants

Start Date

Apr 1, 2023

Study Type

INTERVENTIONAL

Conditions

Lymph Node Metastasis Lung Adenocarcinoma

Summary

This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1018. The goal of this clinical trial is to confirm the theraputic effect of selective lymph node dissection for cT1N0M0 invasive non-small cell lung cancer with CTR\>0.5 located in the apical segment. The main questions it aims to answer are: The 5-year overall survival of patients having cT1N0M0 invasive non-small cell lung cancer with CTR\>0.5 located in the apical segment; The post-operative lymph node metastasis and recurrence-free survival. Participants will receive selective lymph node dissection as the surgical procedure.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two surgical approaches for removing nearby lymph nodes in patients with early-stage non-small cell lung cancer (NSCLC) located in the top part of the lung — to see if a more targeted (less extensive) lymph node removal is just as effective. **You may be eligible if...** - You are between 18 and 80 years old - You have early-stage NSCLC (stage T1, no lymph node or distant spread) located in the top segment of the lung - The cancer is confirmed as invasive (non-lepidic) by frozen section during surgery - You have not previously had lung cancer surgery, chemotherapy, or radiation **You may NOT be eligible if...** - The cancer has spread to lymph nodes or elsewhere - The nodule is not in the top (apical) segment of the lung - The frozen section confirms a non-invasive or non-lung-cancer diagnosis - You have had prior lung cancer surgery, chemotherapy, or radiation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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