A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients with Heart Failure Who Are Intolerant or Not Eligible for Treatment with Steroidal Mineralocorticoid Receptor Antagonists

This trial tests whether finerenone, a newer heart medication, can safely help people with heart failure who cannot tolerate the standard class of medications called steroidal mineralocorticoid receptor antagonists (sMRAs). You may be eligible if... - You are 18 or older - You have symptomatic heart failure with reduced ejection fraction (HFrEF) - You cannot take sMRA medications due to intolerance, contraindications, or ineligibility - Women of childbearing potential must use adequate contraception and have a negative pregnancy test You may NOT be eligible if... - You are already taking a non-steroidal MRA - You have a history of severe high potassium while on MRA medications - Your kidney function (eGFR) is below 25 or your potassium is above 5.0 mmol/L - You recently had a heart attack, heart surgery, or device implant (within 30 days) - You have had or are planning a heart transplant - You have serious heart valve disease, abnormal heart rhythms without a pacemaker, or certain types of cardiomyopathy Talk to your doctor to see if this trial is right for you.