RecruitingPhase 1NCT06034275

Study of VIP943 in Subjects With Advanced CD123+ Hematologic Malignancies

An Open-label, Multicenter Phase 1 Study to Characterize Safety, Tolerability, Preliminary Antitumor Activity, Pharmacokinetics, and Pharmacodynamics of VIP943 Monotherapy in Subjects With Advanced CD123+ Hematologic Malignancies

Sponsor

Vincerx Pharma, Inc.

Enrollment

36 participants

Start Date

Sep 13, 2023

Study Type

INTERVENTIONAL

Conditions

Acute Myeloid Leukemia High Risk Myelodysplastic Syndrome B-cell Acute Lymphoblastic Leukemia

Summary

Dose Escalation - Determine the maximum tolerated dose (MTD), if possible, or minimum optimal biologic dose (OBD), and evaluate the safety and tolerability of VIP943 in subjects with advanced CD123+ hematologic malignancies

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Histologically confirmed AML, B-ALL or MDS. Subjects must have exhausted all available standard therapies or be deemed ineligible for potential available therapies.
Evidence of ≥5% bone marrow or blood blasts (acute leukemia) or ≥5% bone marrow or blood myeloblasts (MDS) to allow for assessment of drug activity.
Evidence of CD123 expression from a local laboratory.
Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2

Exclusion Criteria2

Known central nervous system (CNS) metastases and/or carcinomatous meningitis.
Clinically significant cardiac disease including congestive heart failure \> New York Heart Association (NYHA) Class II), evidence for coronary artery disease (eg, unstable angina (anginal symptoms at rest) or new-onset angina (within the last 6 months or myocardial infarction within the past 6 months before first dose.