RecruitingNot ApplicableNCT06040905

Causal Effect of Coenzyme Q10 Nutrition and Cognitive Dysfunction in the Metabolic Storm (Hyperglycemia and Sarcopenia) and Brain-derived Neurotrophic Factor


Sponsor

Chung Shan Medical University

Enrollment

100 participants

Start Date

Dec 26, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of the study is to investigate the effect of coenzyme Q10 supplementation (150 mg/b.i.d, 300 mg/d, 12 weeks) on coenzyme Q10, glucose parameters, BDNF, myokines, and cognitive function in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients who combined with hyperglycemia but without sarcopenia, or with hyperglycemia and pre-sarcopenia.


Eligibility

Min Age: 50 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is exploring whether taking Coenzyme Q10 supplements (a natural antioxidant) can improve brain function in older adults with mild cognitive impairment or Alzheimer's disease who also have high blood sugar or muscle weakness. **You may be eligible if...** - You have been diagnosed with mild cognitive impairment (MCI) or Alzheimer's disease - You also have elevated fasting blood sugar (100 mg/dL or higher) or signs of muscle weakness/low muscle mass - You are able to swallow tablets **You may NOT be eligible if...** - You have cancer - You have severe heart, lung, liver, or kidney disease - You are significantly malnourished or have had major weight loss recently - You are already taking Coenzyme Q10 supplements - You take the blood thinner warfarin - You have severe disability or are unable to communicate (aphasia) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTCoenzyme Q10

300 mg/day (150mg/b.i.d)

OTHERPlacebo

Starch, dextrin


Locations(1)

Chung Shan Medical University Hospital

Taichung, Taiwan

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NCT06040905


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