RecruitingNot ApplicableNCT06045897

EEG Microstates Across At-Risk Mental States

Determination of EEG Microstates Associated With Mental Disorders in At-Risk States (Détermination Des Microétats EEG associés Aux Troubles Psychiques Dans Les États à Risque - DEMETER)


Sponsor

Centre Hospitalier St Anne

Enrollment

126 participants

Start Date

May 30, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this observational study is to compare subjects with at-risk-mental-state, early psychosis, schizophrenia, depression, and autism spectrum disorders, with healthy controls (N = 21 x 6). The main questions it aims to answer are: * are EEG microstate anomalies associated with diagnosis, clinical and functional prognosis, both in resting conditions and during sleep ? * are EEG microstates anomalies associated with differences in sensorimotor integration, prosodic and conversational, interoceptive, and narrative self ? * an ancillary study will be to see whether in healthy controls EEG microstate properties vary under light hypnosis conditions. Participants will: * undergo deep phenotyping based on psychopathology and neuropsychological assessments * undergo a high-resolution EEG (64 electrodes) with a resting period and a sensorimotor task; and healthy controls will have a light hypnosis period. * undergo a recording of the characteristics of their voice (tone, prosody) * undergo a one-night polysomnography * undergo MRI and biological sampling for multi-omic analyses * undergo a virtual reality experience


Eligibility

Min Age: 15 YearsMax Age: 30 Years

Plain Language Summary

Simplified for easier understanding

This study uses brain wave recordings (EEG) to study patterns of brain activity in people at different risk levels for developing psychosis or other mental health disorders. The goal is to identify early warning signs in brain activity that might help doctors intervene sooner. **You may be eligible if...** - You are between 16 and 35 years old - You have been identified as being at risk for a mental health condition, or you have had a recent first episode of psychosis - You are able to sit still for an EEG recording session **You may NOT be eligible if...** - You have a condition that makes it unsafe to undergo EEG recording - You are already on medications that significantly affect brain wave patterns - You have severe cognitive impairment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEEEG 64 channels

64-channel EEG in wake and resting conditions for 1h30, with oculogram, electromyogram and electromyogram and electrocardiogram. Five minutes of eyes closed will be used for microstate analysis. 1h30 will be used for the sensorimotor task.

DEVICEPolysomnography 19 electrodes

Overnight polysomnography with 19 EEG channels and ventilatory polygraphy.

BEHAVIORALLight hypnosis

Healthy controls will undergo a 5 min light hypnosis exercise that will be focused on proprioception.

BIOLOGICALBiological sampling

Blood samples will be taken for genetic, epigenetic, proteomic, and metabolomic studies.

BEHAVIORALVirtual reality

Participants will undergo a virtual reality task using a head-mounted display, and their multidimensional self will be assessed prior to and after the task via the self-reference effect on episodic memory.

DEVICEVoice recording

A double channel audio recorder will be used during 30 min to assess voice characteristics of all subjects.


Locations(1)

Centre de Recherche Clinique, Hôpital Sainte-Anne, GHU Paris Psychiatrie et Neurosciences

Paris, France

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NCT06045897


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