Pulmonary Artery DenerVation Clinical Study Using the Gradient Denervation System in Heart Failure Patients With Pulmonary Hypertension Group 2 (PreVail-PH2 Study)

This study tests a procedure called pulmonary artery denervation — where nerve fibers around the pulmonary artery are disrupted using a special catheter — in heart failure patients who also have high blood pressure in their lung arteries (pulmonary hypertension). The goal is to reduce lung artery pressure and improve heart function. **You may be eligible if...** - You have heart failure with a preserved or mildly reduced pumping function - Your lung artery pressure is elevated and measured by a heart catheter procedure - You have been on stable, guideline-recommended heart failure treatment for at least 3 months - You are in NYHA functional class II or III (moderate symptoms) **You may NOT be eligible if...** - Your life expectancy is less than 1 year - You cannot take blood-thinning medications or have an allergy to aspirin or clopidogrel - You cannot tolerate a right heart catheter procedure - You have a pulmonary artery aneurysm or significant narrowing of the pulmonary artery Talk to your doctor to see if this trial is right for you.