RecruitingNCT06054854

Biobank for the Identification of Biomarkers in Lung Cancer (BIRD, Biomarkers in Respiratory Disease)

Biobank for the Identification of Diagnostic, Prognostic or Therapeutic (Response and Resistance) Biomarkers in Lung Cancer (Early and Advanced Stages of Lung Cancer Cohort of the BIRD (Biomarkers in Respiratory Disease) Biobank)

Sponsor

University Hospital, Toulouse

Enrollment

3,000 participants

Start Date

Jun 13, 2024

Study Type

OBSERVATIONAL

Conditions

Lung Cancer Lung Nodule

Summary

The BIRD biobank aims at collecting clinical and biological data from patients suffering from a chronic respiratory disease. The lung cancer subpopulation will be divided into two cohorts to identify biomarkers of cancer. One cohort will include patients with supra-centimetric lung nodule(s) whether surveillance, bronchoscopic or radio-guided biopsy or surgery is indicated, patients suspected of lung cancers requiring diagnostic and/or therapeutic bronchial endoscopy and patients with a known early stage lung cancer (early-stage cohort). The second cohort will include known advanced stage lung cancers (III-IV).

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Patients with 1 to 3 lung nodules including one \> 1 cm seen on chest CT
OR: patients with suspected lung cancer requiring diagnostic and/or therapeutic bronchial endoscopy
OR: Patient with histologically confirmed lung cancer, whether early stages prior to surgery, locally advanced or metastatic, included before the start of any anti-cancer treatment.
Patient affiliated or beneficiary of a social security scheme
Patients who are able to receive and understand information about the study and their participation and who have freely given their signed inform consent before any collection of samples or data necessary for the research (no restriction of rights by the judicial authorities and knowledge of the French language).

Exclusion Criteria2

Patient deprived of liberty on administrative or judicial decision, or patient under guardianship, curators or safeguard of justice
Female patients who are pregnant or breastfeeding

Interventions

BIOLOGICALExtra blood sampling, Non-invasive or leftover samples or medical waste

Extra blood sampling, Urine, Saliva, Stool, Superficial nasal swamp sampling. Bronchoalveolar lavage fluid, Mediastinal node or mass, Peripheral nodule aspiration supernatant, Pleural fluid, Cerebrospinal fluid collection (leftover samples or medical waste). Blood will be collected in larger quantity during a blood test planned as part of the patient's care. Non-invasive or leftover samples or medical waste will be collected on top of the usual diagnosis and during follow-up, depending on the case.