Tranexamic Acid in Nasal Mohs Reconstruction
Subcutaneous Tranexamic Acid in Nasal Mohs Local Flap Reconstruction: Perioperative Bleeding, Edema, and Ecchymosis
Vanderbilt University Medical Center
100 participants
Mar 19, 2024
INTERVENTIONAL
Conditions
Summary
This study will be a prospective randomized control trial to evaluate the effects of subcutaneously administered TXA among patients undergoing nasal Mohs reconstruction with local flaps at VUMC.
Eligibility
Inclusion Criteria2
- Adults at least 18 years of age undergoing local flap reconstruction (bilobe flap, note flap dorsal nasal flap, advancement flap) of a nasal defect following Mohs micrographic surgery. Reconstructive procedures will be performed by Drs. Yang or Patel in the division of Facial Plastic Surgery in the Department of Otolaryngology, Head and Neck Surgery at Vanderbilt University Medical Center.
- No other facial plastic procedure or sinus surgery performed simultaneously.
Exclusion Criteria12
- Known allergy to TXA
- Intracranial bleeding
- Known defective color vision
- History of venous or arterial thromboembolism
- History of coagulation disorder
- Active thromboembolic disease
- Severe renal impairment (diagnosis of chronic kidney disease)
- History of acute myocardial infarction
- History of stroke
- History of seizure
- History of liver failure
- Preoperative lab results indicating thrombocytopenia (platelets <150,000), increased bleeding risk (PT over 45, INR over 1.2).
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Interventions
Subcutaneous injection of local anesthetic (1% lidocaine with 1:100,000 epinephrine) and tranexamic acid (1g/10mL), mixed in a 9:1 volume ratio.
Subcutaneous injection of local anesthetic (1% lidocaine with 1:100,000 epinephrine)
Locations(1)
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NCT06057675