RecruitingPhase 3NCT06058585

The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect

Sponsor

The George Institute

Enrollment

1,000 participants

Start Date

Sep 4, 2024

Study Type

INTERVENTIONAL

Conditions

Chronic Kidney Diseases

Summary

CAPTIVATE is an international, multi-centre, Phase III, adaptive, platform, randomised controlled trial in people with chronic kidney disease (CKD). CAPTIVATE aims to find the best treatment, or combination of treatments, that slow the progression of CKD so that fewer people develop kidney failure. CAPTIVATE provides a research platform that allows many treatment-related questions to be answered within a common trial set-up.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is a large adaptive clinical trial testing various treatments for people with chronic kidney disease (CKD). 'Adaptive' means the study can adjust which treatments are tested based on results as the trial progresses. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with chronic kidney disease from any cause, with kidneys still filtering at least 25% of normal capacity - You are already receiving standard care for your kidney disease - You and your doctor are willing to follow the trial procedures **You may NOT be eligible if...** - You are expected to start dialysis or have a kidney transplant in the next 6 months - You have a very limited life expectancy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGFinerenone

Finerenone 10mg or 20mg tablets, oral, once daily

DRUGPlacebo Finerenone

Finerenone matched placebo tablets, oral, once daily

Locations(43)

The Canberra Hospital

Garran, Australian Capital Territory, Australia

Nepean Blue Mountains Local Health District

Kingswood, New South Wales, Australia

St George Hospital

Kogarah, New South Wales, Australia

John Hunter Hospital

New Lambton Heights, New South Wales, Australia

Westmead Hospital

Westmead, New South Wales, Australia

Sunshine Coast Hospital and Health Service

Birtinya, Queensland, Australia

Townsville University Hospital

Douglas, Queensland, Australia

West Moreton Hospital & Health Service

Ipswich, Queensland, Australia

Gold Coast Hospital and Health Service

Southport, Queensland, Australia

Royal Adelaide

Adelaide, South Australia, Australia

Lyell McEwin Hospital

Elizabeth Vale, South Australia, Australia

Austin Health

Heidelberg, Victoria, Australia

South Metropolitan Health Service, Fiona Stanley Hospital

Murdoch, Western Australia, Australia

Gitam Institute of Medical Sciences and Research

Visakhapatnam, Andhra Pradesh, India

Patna Medical College and Hospital

Patna, Bihar, India

DKS Super Speciality Hospital, Raipur

Raipur, Chhattisgarh, India

Mysore Medical College

Dehradun, Dehradun, India

GCS Medical College, Hospital & Research Centre

Ahmedabad, Gujarat, India

Father Muller Medical College Hospital

Mangaluru, Karnataka, India

Dr Moopen's Medical College

Meppādi, Kerala, India

CARE-CHL Hospital

Indore, Madhya Pradesh, India

Medway Hospital

Chennai, Tamil Nadu, India

Yashoda Hospital Hitec City

Hyderabad, Telangana, India

Apollo Hospitals

Hyderabad, Telangana, India

Charak Hospital and Research Centre

Lucknow, Uttar Pradesh, India

Shri Guru Ram Rai Medical College and Shri Mahant Indiresh Hospital

Dehradun, Uttarakhand, India

Fortis Hospital

Kolkata, West Bengal, India

North Bengal Medical College & Hospital

Siliguri, West Bengal, India

Max Superspeciality Hospital, Dehradun

Dehradun, India

Health New Zealand, Te Whatu Ora Te Matau a Maui, Hawke's Bay Hospital

Hastings, Hawkes Bay, New Zealand

Health New Zealand, Te Whatu Ora Waitemata, North Shore Hospital

Auckland, New Zealand

Auckland City Hospital

Auckland, New Zealand

Aotearoa Clinical Trials Trust, Middlemore Hospital

Auckland, New Zealand

201 Great King Street, Central Dunedin, Dunedin 9016, New Zealand

Dunedin, New Zealand

Private Bag 9742 Maunu Road, Horahora, Whangārei 0148, New Zealand

Whangarei, New Zealand

Hospital Clinico Universitario València (INCLIVA)

Valencia, Espana, Spain

National Nephrology Specialized Hospital

Colombo, Polonnaruwa, Sri Lanka

National Hospital of Sri Lanka

Colombo, Sri Lanka

Kandy National Hospital

Kandy, Sri Lanka

Kurunegala Teaching Hospital

Kurunegala, Sri Lanka

Sri Jayewardenepura General Hospital

Nugegoda, Sri Lanka

Peradeniya Teaching Hospital

Peradeniya, Sri Lanka

Colombo North Teaching Hospital

Ragama, Sri Lanka

View Full Details on ClinicalTrials.gov

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NCT06058585

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