Geno-radiomics Based Model for Evaluation of Immunotherapy and Targeted Therapy for Advanced Soft Tissue Sarcoma

This study is building a predictive model combining genomic data (tumor genetics) and radiomic data (patterns extracted from imaging scans) to help guide immunotherapy and targeted therapy decisions for patients with advanced soft tissue sarcoma. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with unresectable locally advanced or metastatic soft tissue sarcoma, including types such as leiomyosarcoma, angiosarcoma, fibrosarcoma, epithelioid sarcoma, and others - You are scheduled to receive immunotherapy or targeted therapy **You may NOT be eligible if...** - You have certain excluded cancer types (gastrointestinal stromal tumor, osteosarcoma, chondrosarcoma, etc.) - Your tumor cannot be biopsied - You have severe organ problems affecting treatment safety Talk to your doctor to see if this trial is right for you.