Advanced Soft Tissue Sarcoma Clinical Trials

14 recruiting

Frequently Asked Questions

Common questions about Advanced Soft Tissue Sarcoma clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 116 of 16 trials

Recruiting
Phase 1Phase 2

Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma

Metastatic Soft Tissue SarcomaMetastatic LeiomyosarcomaAdvanced Soft Tissue Sarcoma+5 more
National Cancer Institute (NCI)74 enrolled1 locationNCT06498648
Recruiting
Phase 2

Testing Atezolizumab With Selinexor in People ≥ 12 Years Old With Alveolar Soft Part Sarcoma, The AXIOM Trial

Metastatic Alveolar Soft Part SarcomaAdvanced Soft Tissue SarcomaAdvanced Alveolar Soft Part Sarcoma+2 more
National Cancer Institute (NCI)27 enrolled13 locationsNCT05333458
Recruiting
Not Applicable

Superiority Trial Evaluating Digitalized Information Media for Patients With Advanced Sarcomas Receiving Systemic Treatment.

Sarcoma MetastaticLocally Advanced Soft Tissue Sarcoma
Centre Oscar Lambret377 enrolled11 locationsNCT06211257
Recruiting
Phase 1

Actinium Therapy for Late-stage Aggressive Sarcomas

Advanced Soft Tissue Sarcoma
Ratio Therapeutics, Inc.30 enrolled6 locationsNCT07156565
Recruiting
Phase 2

Doxorubicin Plus Dual Checkpoint Blockade for Soft Tissue Sarcomas

Metastatic Soft Tissue SarcomaAdvanced Soft Tissue Sarcoma
University of Colorado, Denver65 enrolled1 locationNCT04028063
Recruiting
Phase 2

Pegylated Liposomal Doxorubicin (PLD) Versus Active Surveillance for Advanced Soft Tissue Sarcoma Patients Who Had Controlled Disease After Standard Anthracycline-based Treatment (MELODY)

Advanced Soft Tissue Sarcoma
National Health Research Institutes, Taiwan81 enrolled7 locationsNCT06981637
Recruiting
Phase 2

Combination of Pembrolizumab and Cabozantinib in Patients With Advanced Sarcomas

OsteosarcomaEwing SarcomaSoft Tissue Sarcoma Adult+2 more
Institut Bergonié119 enrolled10 locationsNCT05182164
Recruiting
Phase 2

Bintrafusp Alfa and Doxorubicin Hydrochloride in Treating Patients With Advanced Sarcoma

Metastatic Soft Tissue SarcomaAdvanced Soft Tissue Sarcoma
Institut Bergonié80 enrolled8 locationsNCT04874311
Recruiting
Phase 2

A Trial of Cadonilimab With Adriamycin in Patients With Advanced Soft Tissue Sarcoma

Advanced Soft Tissue Sarcoma
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology53 enrolled1 locationNCT06367075
Recruiting
Phase 3

Comparison of Oral Cyclophosphamide vs Doxorubicin in ≥65 Years Old Advanced or Metastatic Soft Tissue Sarcoma Patients

Metastatic Soft Tissue SarcomaAdvanced Soft Tissue Sarcoma
UNICANCER214 enrolled1 locationNCT04757337
Recruiting
Phase 1Phase 2

Multicohort Trial of Different Schemes of PM14 in Monotherapy and in Combination with Radiotherapy in Soft Tissue Sarcomas and Other Solid Tumor

Advanced Solid TumorAdvanced Soft Tissue SarcomaAdvanced L-sarcomas+2 more
Grupo Espanol de Investigacion en Sarcomas195 enrolled4 locationsNCT05146440
Recruiting
Phase 1Phase 2

SAINT:Trabectedin, Ipilimumab and Nivolumab for Previously Treated Advanced Soft Tissue Sarcoma

Metastatic Soft Tissue SarcomaAdvanced Soft Tissue Sarcoma
Sarcoma Oncology Research Center, LLC250 enrolled1 locationNCT03138161
Recruiting

The Value of 68Ga-grazytracer PET in Monitoring Responses to Immunotherapy of Advanced Soft Tissue Sarcomas

Advanced Soft Tissue Sarcomas
Ruijin Hospital40 enrolled1 locationNCT06644287
Recruiting
Phase 1Phase 2

LINNOVATE: Lurbinectedin, Ipilimumab and Nivolumab for Soft Tissue Sarcoma

Advanced Soft Tissue Sarcoma
ERLINDA M GORDON40 enrolled1 locationNCT05876715
Recruiting

Geno-radiomics Based Model for Evaluation of Immunotherapy and Targeted Therapy for Advanced Soft Tissue Sarcoma

Advanced Soft Tissue Sarcoma
Peking Union Medical College Hospital60 enrolled1 locationNCT06062927
Recruiting
Not Applicable

Study of NY-ESO-1 TCR-T in Advanced Soft Tissue Sarcoma

Advanced Soft Tissue Sarcoma
Shenzhen University General Hospital20 enrolled1 locationNCT05620693