RecruitingNCT06065306

Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department

Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department: the Aggrecan, Desmosine, D-dimer-Emergency Department (ADD-ED) Study

Sponsor

Chinese University of Hong Kong

Enrollment

47 participants

Start Date

Jun 18, 2023

Study Type

OBSERVATIONAL

Conditions

Aortic Dissection

Summary

The goal of this observational study is to determine the utility of desmosine, D-dimer and aggrecan as early diagnostic biomarkers in aortic dissection. The main questions it aims to answer are: * To investigate the plasma levels of selected biomarkers in ED patients with confirmed aortic dissection * To study the diagnostic performance of plasma levels of selected biomarkers for aortic dissection * To study the association between plasma levels of selected biomarkers and clinical outcomes

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Age ≥ 18 years
Presentation to the ED with first 24 hours of symptoms suggesting AD, including chest pain, upper back pain, syncope of unknown cause, symptoms of any acute perfusion deficit
Confirmed AD
the diagnosis of AD adjudicated by an independent expert panel at hospital discharge or death, whichever comes first
The expert panel will consist of (1) a specialist in Emergency Medicine and (2) a specialist in Cardiology and (3) a specialist in Cardiothoracic Surgery.